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馬兜鈴酸A

分析標(biāo)準(zhǔn)品,HPLC≥98%

Aristolochic acid A

CAS號：313-67-7

分子式：C17H11NO7

分子量：341.27

MDL：MFCD00004996

別名：馬兜鈴酸 A; 8-甲氧基-3,4-亞甲二氧基-10-硝基菲-1-甲酸; 氧環(huán)菲甲酸

產(chǎn)品介紹

Aristolochic acid A (Aristolochic acid I; TR 1736) 是植物提取物 Aristolochic acids 的主要成分，其存在于 Aristolochia 和 Asarum 草本植物中。Aristolochic acid A 顯著降低激活蛋白1 (AP-1) 和 NF-κB 活性。Aristolochic acid A 降低人細(xì)胞中膀胱癌相關(guān) BLCAP 基因表達(dá)。

熔點(diǎn)：260 ℃

沸點(diǎn)：615.5℃ at 760 mmHg

外觀：棕色結(jié)晶

溶解性：溶于乙醇、氯仿、乙mi、丙tong、醋酸、苯胺及堿，微溶于堿，幾乎不溶于苯及二硫化碳。

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(16篇)

16. [IF=7.6] Yujie Zhang et al."High-resolution mass spectrometry-based suspect and nontarget screening of natural toxins in foodstuffs and risk assessment of dietary exposure."ENVIRONMENTAL POLLUTION.2024 Nov;:125338

15. [IF=2.1] Jian-hui Zhang et al."Eleutherococcus senticosus Alleviates Aristolochic-Acid-Induced Acute Kidney Damage by Inhibiting the NLRP3/IL-1β Signaling Pathway in Mice."PLANTA MEDICA.2025 Jan;:

14. [IF=4.1] Hua Zhang et al."Immunotoxicity of aristolochic acid I on early zebrafish (Danio rerio) embryos."FISH & SHELLFISH IMMUNOLOGY.2025 Apr;:110305

13. [IF=2.6] Long Xu et al."Development of chemiluminescent enzyme immunoassay for the detection of aristolochic acid I in patent medicines and cosmetics."TOXICON.2025 Jun;260:108362

12. [IF=6.2] Ying Hu et al."Palmatine reverse aristolochic acid-induced heart failure through activating EGFR pathway via upregulating IKBKB."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Oct;285:117100

11. [IF=3.6] Dian Jiao et al."A pumpless liver-on-a-chip for drug hepatotoxicity analysis."ANALYST.2024 Jul;:

10. [IF=7.4] Xiaoqi Chen et al."Development and Application of a Comprehensive Nontargeted Screening Strategy for Aristolochic Acid Analogues."ANALYTICAL CHEMISTRY.2024;XXXX(XXX):XXX-XXX

9. [IF=3.571] Ziyan Xu et al."In vitro Nephrotoxicity and Quantitative UPLC-MS Analysis of three Aristololactams in Houttuynia Cordata."JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS.2023 Feb;:115289

8. [IF=5.168] Pan Wang et al."Discovery and characterization of novel ATP citrate lyase inhibitors from natural products by a luminescence-based assay."CHEMICO-BIOLOGICAL INTERACTIONS.2022 Nov;367:110199

7. [IF=6.064] Xiaohan Wang et al."Microbial degradation of aristolochic acid I by endophytic fungus A.h-Fs-1 of Asarum heterotropoides."Frontiers in Microbiology.2022; 13: 917117

6. [IF=3] Qu  Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950

5. [IF=4.171] Chengni Jin et al."The renoprotective effect of diosgenin on aristolochic acid I-induced renal injury in rats: impact on apoptosis, mitochondrial dynamics and autophagy."Food Funct. 2020 Sep;11(9):7456-7467

4. [IF=7.46] Si-Qi Wu et al."Gold nanoclusters-based paper sensor for the visualized detection of nephrotoxic aristolochic acids."Sensor Actuat B-Chem. 2021 Aug;340:129792

3. [IF=7.514] Huihuang Xiong et al."Thermosensitive and magnetic molecularly imprinted polymers for selective recognition and extraction of aristolochic acid I."Food Chem. 2022 Mar;372:131250

2.  邵珠瑩,潘金火,張月嬋,蔣志濤,王雪,馮星月,王建春.6-姜酚對馬兜鈴酸A誘導(dǎo)的HK-2腎小管上皮細(xì)胞損傷的保護(hù)作用[J].中成藥,2020,42(10):2744-2747.

1.  尹浩, 陳爍吉, 田小亭,等. 基于HPLC-Q-TOF/MS法分析馬兜鈴水煎劑化學(xué)成分的研究[J]. 世界科學(xué)技術(shù):中醫(yī)藥現(xiàn)代化, 2019(7).

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